abstract：:Abnormal nutritional status is an increasingly common complication in developed countries and, as reproductive age women are a part of this trend, the effect of maternal obesity on the pregnancy and neonate must be investigated. Pregestational obesity or overweight condition or an excessive gestational weight gain can...

journal_title：Journal of endocrinological investigation

authors： Triunfo S,Lanzone A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Due to the lack of specific pediatric studies, no data are available about natural history of endogenous subclinical hyperthyroidism (SH) in childhood. AIMS:(a) To investigate for the first time the natural history of SH [suppressed thyrotropin (TSH) and normal free thyroxine free thyroxine (FT4) levels] wh...

journal_title：Journal of endocrinological investigation

authors： Aversa T,Valenzise M,Corrias A,Salerno M,Mussa A,Capalbo D,Salzano G,De Luca F,Wasniewska M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Myogenesis is susceptible to the availability of nutrients and humoral factors and suboptimal fetal environments affect the number of myofibers and muscle mass. AIM:We examined the mechanisms regulating cell cycle progression and arrest in skeletal myoblasts. MATERIALS AND METHODS:Mouse C2C12 myoblasts wer...

journal_title：Journal of endocrinological investigation

authors： Grabiec K,Gajewska M,Milewska M,Błaszczyk M,Grzelkowska-Kowalczyk K

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Leptin and ghrelin appear to play a role in weight regain after a successful weight loss. The pre-treatment plasma levels of leptin/ghrelin ratio (L/G) could have power to predict this clinically relevant issue in the obesity treatment. OBJECTIVE:To evaluate the ability of the L/G as a non-invasive tool for...

journal_title：Journal of endocrinological investigation

authors： Crujeiras AB,Díaz-Lagares A,Abete I,Goyenechea E,Amil M,Martínez JA,Casanueva FF

更新日期：2014-02-01 00:00:00

abstract：AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...

journal_title：Journal of endocrinological investigation

authors： Gramaglia E,Ramella Gigliardi V,Olivetti I,Tomelini M,Belcastro S,Calvi E,Dotta A,Ghigo E,Benso A,Broglio F

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:In obese subjects it has been shown that cortisol (F) contributes to the reduction in insulin sensitivity, suggesting a role in the development of the metabolic syndrome (MS). AIM:The aim of this retrospective study was to evaluate the relationship between F and components of MS in 1,027 obese children and ...

journal_title：Journal of endocrinological investigation

authors： Guzzetti C,Pilia S,Ibba A,Loche S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Non-exercise activity thermogenesis has recently drawn attention because of its potential to prevent weight gain. AIM:This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance (IR) in the Japanese population....

journal_title：Journal of endocrinological investigation

authors： Uemura H,Katsuura-Kamano S,Yamaguchi M,Nakamoto M,Hiyoshi M,Arisawa K

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Increasing evidence showed that telomere length was shorter in age-related diseases, but the mechanism of this phenomenon is still unclear. AIM:To determine whether telomere shortening occurs in Type 1 diabetes (T1D) and Type 2 diabetes (T2D), and explore the effect of antioxidant status on the telomere len...

journal_title：Journal of endocrinological investigation

authors： Ma D,Zhu W,Hu S,Yu X,Yang Y

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:We previously identified a four-generation family with medullary thyroid cancer (MTC) and a germline p.Y791F RET mutation whose cancer lacked a strong genotype-phenotype correlation. The entire gene coding region of the RET gene should be sequenced when genotype-phenotype discrepancies are observed in patien...

journal_title：Journal of endocrinological investigation

authors： Valente FO,Dias da Silva MR,Camacho CP,Kunii IS,Bastos AU,da Fonseca CC,Simião HP,Tamanaha R,Maciel RM,Cerutti JM

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Immune dysfunction is very common in diabetes mellitus (DM). However, there is no evidence whether such immune dysfunction can influence the development of DM, especially the development of diabetic nephropathy (DN). AIM:To investigate the influence of absence of T cells on DN. MATERIALS AND METHODS:Balb/c...

journal_title：Journal of endocrinological investigation

authors： Lin S,Xu PC,Huang QE,Jia JY,Jia ZH,Wei L,Zheng ZF,Shang WY

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:No data on the prevalence of erectile dysfunction (ED) in subjects with newly diagnosed Type 2 diabetes mellitus (T2DM) are currently available. AIM:The aim of the present study was to estimate the prevalence of ED and its associated causes in a sample of male patients with recently diagnosed DM (<24 mont...

journal_title：Journal of endocrinological investigation

authors： Corona G,Giorda CB,Cucinotta D,Guida P,Nada E,SUBITO-DE study group.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Fine needle cytology aspirates (FNA) classified as THY4 are a heterogeneous group suspicious for malignancy [papillary thyroid cancer (PTC)], which is confirmed in 50-80% of cases after surgery. AIM:To better stratify THY4 FNA specimens for the relative risk of malignancy. METHODS:We retrospectively analyz...

journal_title：Journal of endocrinological investigation

authors： Arena S,Latina A,Marturano I,Muscia V,La Rosa GL,Stornello M,Squatrito S,Italia S,Vigneri R

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stres...

journal_title：Journal of endocrinological investigation

authors： Ghalami J,Zardooz H,Rostamkhani F,Farrokhi B,Hedayati M

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The adiponectin gene has been identified as a susceptibility locus for metabolic syndrome, diabetes and cardiovascular disease. AIM:To examine the influence of two single nucleotide polymorphisms (SNPs) of this gene (+276G>T and +45T>G) on circulating adiponectin concentrations, and to evaluate their relati...

journal_title：Journal of endocrinological investigation

authors： Galcheva SV,Martorana D,Iotova VM,Yotov Y,Neri TM,Street ME

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The data about cardiovascular (CV) changes in patients with asymptomatic primary hyperparathyroidism (PHPT) are scarce. AIM:The aim of this study is to compare cardiac structure and functions in patients with asymptomatic PHPT and controls by using tissue Doppler echocardiography. SUBJECTS AND METHODS:Thir...

journal_title：Journal of endocrinological investigation

authors： Aktas Yılmaz B,Akyel A,Kan E,Ercin U,Tavil Y,Bilgihan A,Cakır N,Arslan M,Balos Toruner F

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its potent analog, exendin-4, are well known to inhibit β- cell apoptosis and promote β-cell proliferation. Meanwhile, cytokines, such as interleukin-1β (IL-1β), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to β-cell d...

journal_title：Journal of endocrinological investigation

authors： Liu XH,Wang YP,Wang LX,Chen Z,Liu XY,Liu LB

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Functional hypothalamic amenorrhea (FHA) refers to a functional menstrual disorder with various causes and presentations. Recovery of menstrual cyclicity is common in long-term follow-up but the affecting factors remain unknown. AIM:To explore factors affecting the menstrual resumption and to evaluate the p...

journal_title：Journal of endocrinological investigation

authors： Shen ZQ,Xu JJ,Lin JF

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Several studies investigated the possible role of adipokines during chronic viral hepatitis, not producing defined results neither clearly establishing their behavior in course of anti-viral treatment. Our study evaluated blood concentrations of adiponectin and resistin in patients with chronic hepa...

journal_title：Journal of endocrinological investigation

authors： Durazzo M,Belci P,Niro G,Collo A,Grisoglio E,Ambrogio V,Spandre M,Fontana R,Gambino R,Cassader M,Bo S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...

journal_title：Journal of endocrinological investigation

authors： Vaisman F,Coeli CM,Ward LS,Graf H,Carvalho G,Montenegro R Jr,Vaisman M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The aim of the current study was to evaluate the association of osteoprotegerin and vascular endothelial growth factor (VEGF) with glycemic indices and diabetes status. METHODS:A total of 44 normoalbuminuric Type 1 diabetic patients and 44 healthy control subjects, matched for age, body mass index, sex rati...

journal_title：Journal of endocrinological investigation

authors： Esteghamati A,Arefzadeh A,Zandieh A,Salehi Sadaghiani M,Noshad S,Nakhjavani M

更新日期：2013-07-01 00:00:00

abstract：:Androgens' metabolism and activity are gaining a more and more important role in human physiology particularly referring to aging and to neurodegenerative diseases. Androgen treatment is often required for long-lasting disorders. In order to improve their duration and effects, androgens can be administered as esters o...

journal_title：Journal of endocrinological investigation

authors： Aiello F,Garofalo A,Aloisi AM,Lamponi S,Magnani A,Petroni A

更新日期：2013-06-01 00:00:00

abstract：:Because women affected by polycystic ovary syndrome (PCOS) present an increased cardiovascular risk, the safety of estroprogestin treatment is debated and contrasting data have been reported. However, cardiovascular risk is not the same in all PCOS women and individual cardiovascular risk should be assessed before sta...

journal_title：Journal of endocrinological investigation

authors： Carmina E

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Type 1 diabetes (T1DM) is an autoimmune disease in which both genetic and environmental factors play a role in the etiology. AIM:The aim of this study was to analyze the incidence of T1DM. METHODS:A retrospective technique was used to register all newly diagnosed cases of T1DM in Belgrade (Serbia) children...

journal_title：Journal of endocrinological investigation

authors： Sipetic S,Maksimovic J,Vlajinac H,Ratkov I,Sajic S,Zdravkovic D,Sipetic T

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Elevated plasminogen activator inhibitor type 1 (PAI 1) plays an important role in the pathogenesis of excess blood coagulability in obese patients. L-arginine supplementation has shown to be associated with enhanced cardiovascular and metabolic health. The aim of the study was to assess the effect of L-argi...

journal_title：Journal of endocrinological investigation

authors： Bogdanski P,Szulinska M,Suliburska J,Pupek-Musialik D,Jablecka A,Witmanowski H

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Neonatal hypothyroidism has serious effects on growth, development, and metabolism. AIM:This study aims to investigate the effects of the neonatal hypothyroidism on carbohydrate metabolism, islet insulin secretion and morphology of the pancreatic islets in adult male offspring. MATERIALS/SUBJECTS AND METHO...

journal_title：Journal of endocrinological investigation

authors： Farahani H,Ghasemi A,Roghani M,Zahediasl S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...

journal_title：Journal of endocrinological investigation

authors： Martins de Almeida JF,Gonçalves Tsumura W,Vaisman M,Montalli Assumpção LV,Ward LS

更新日期：2012-11-01 00:00:00

abstract：:Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different labor...

journal_title：Journal of endocrinological investigation

authors： Rigamonti AE,Bozzola M,Banfi G,Meazza C,Müller EE,Cella SG

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Apart from waist circumference, other adiposity measures, such as subscapular skin fold (SST), arouse growing interest due to their relationship to metabolic complications and cardiovascular risk. The IGF-I system is deregulated in obese subjects in proportion to their degree of visceral adiposity. AIM:To e...

journal_title：Journal of endocrinological investigation

authors： Savastano S,Barbato A,Di Somma C,Guida B,Pizza G,Barrea L,Avallone S,Schiano di Cola M,Strazzullo P,Colao A

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:We designed a single-center retrospective study to assess the QT interval duration and to describe cardio vascular events among patients treated with mitotane for a adrenocortical carcinoma (ACC). DESIGN:We selected 14 patients (6 males and 8 females) that met the following criteria: ACC treated with mitotan...

journal_title：Journal of endocrinological investigation

authors： Ederhy S,Cohen A,Dufaitre G,Chaderevian R,Abbas H,Bertagna X,Libé R

更新日期：2012-11-01 00:00:00

abstract：AIM:We investigated inpatients with and without Type 2 diabetes mellitus, aged over 60 yr, to compare their vitamin D status and calcium homeostatic parameters. MATERIALS AND METHODS:We studied 140 patients consecutively admitted to our Internal Medicine Unit during the year 2010 (61 from November to April, 79 from Ma...

journal_title：Journal of endocrinological investigation

authors： Carnevale V,Inglese M,Annese MA,De Matthaeis A,Santini SA,Frusciante V,Fontana A,Copetti M,Pellegrini F,D'Amico G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Subclinical thyroid dysfunctions may cause cognitive deficits and mood disorders. Chronic TSH-suppressive therapy with L-T(4) causing subclinical hyperthyroidism has been widely used in treatment of patients with thyroid differentiated carcinoma. The impact of this therapy on cognitive functions and mood hav...

journal_title：Journal of endocrinological investigation

authors： Jaracz J,Kucharska A,Rajewska-Rager A,Lacka K

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Elevated γ-glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) could predict the risk of Type 2 diabetes (T2D), but the reason for their elevation was unclear. GGT and ALT mediated the metabolism of many amino acids (AA). Up to now, it was not investigated whether abnormal AA concentration was a...

journal_title：Journal of endocrinological investigation

authors： Chen T,Zhang X,Long Y,Yu H,Ran X,Gao Y,Lu H,Xie X,Chen X,Ren Y,Shi J,Tian H

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. Hypoxia inducible factor-1α (HIF-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. AIM:We determined whether maternal blood c.1722C>T (Pro582Ser) and c.1790G>A (Ala...

journal_title：Journal of endocrinological investigation

authors： Kim SY,Park SY,Lim JH,Lee BY,Yang JH,Ryu HM

更新日期：2012-07-01 00:00:00

abstract：:Diagnosis of endogenous hyperinsulinism caused by insulinoma is based on confirmation of hypoglycemia during the symptoms associated to elevated insulin levels. Patients with insulinoma may demonstrate an excessive insulin response and subsequent hypoglycemia after 1 mg of glucagon iv injection. Glucagon test was perf...

journal_title：Journal of endocrinological investigation

authors： Felício JS,Martins CL,Mileo KB,Semer M,Kalinin L,Nery M,Machado MC,Liberman B

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of cardiovascular risk factors in patients with primary hyperparathyroidism (PHPT) and to determine if they are gender specific. METHODS:This was a retrospective case control study. Three hundred and sixty-three men and women with PHPT and 363 age-, sex-, and body mass index (BM...

journal_title：Journal of endocrinological investigation

authors： Han D,Trooskin S,Wang X

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Adipose tissue has emerged as an important endocrine regulator by secreting hormones referred to as adipokines. Recent studies showed that adipose tissue considerably responds to hypoxia. Although the impact of white adipose tissue on regulative processes is established, the importance of brown adipose tissu...

journal_title：Journal of endocrinological investigation

authors： Wree A,Mayer A,Westphal S,Beilfuss A,Canbay A,Schick RR,Gerken G,Vaupel P

更新日期：2012-05-01 00:00:00

abstract：:Hypoparathyroidism cannot be cured by oral or intravenous calcium supplements. Using molecular biology techniques to induce the production of PTH is an ideal option to treat hypoparathyroidism. In this study, we established a recombinant plasmid encoding a mutant preproPTH with a skeletal muscle creatine kinase promot...

journal_title：Journal of endocrinological investigation

authors： Liu D,Zhu Y,Yang C,Long J,Yao C,Li J,Wang S

更新日期：2012-05-01 00:00:00

abstract：:Scavenger receptor A (SR-A) is the main receptor through which oxidized LDL (oxLDL) and advanced glycation end products get into the cells. The aim of the present study was to investigate the effect of an ACE inhibitor, perindopril, on the expression of SR-A in renal tubulointerstitium of diabetic rats. Diabetes was i...

journal_title：Journal of endocrinological investigation

authors： Sun L,Wen JH,Sun HL,Shu XC,Hu F,Yin DC,Yang Q,Zeng YJ,Sun Y,Liu L

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Adiponectin, a fat derived cytokine, is a potential independent contributor to bone mineral density (BMD); however, its action on bone metabolism in humans is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin with bone mass indices and bone metabolic markers in midd...

journal_title：Journal of endocrinological investigation

authors： Tenta R,Kontogianni MD,Yiannakouris N

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is frequently observed in patients with acromegaly. Current therapies for acromegaly may impact glucose regulation, influencing insulin sensitivity and secretion. The question whether these therapies modify control and progression of diabetes once present is still open. AIM:Aim of our stud...

journal_title：Journal of endocrinological investigation

authors： Cambuli VM,Galdiero M,Mastinu M,Pigliaru F,Auriemma RS,Ciresi A,Pivonello R,Amato M,Giordano C,Mariotti S,Colao A,Baroni MG

更新日期：2012-02-01 00:00:00